gene

OXIDATIVE STRESS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about OXIDATIVE STRESS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

9849Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

OXIDATIVE STRESS is a gene implicated in neurodegeneration research. Key relationships include: activates, therapeutic target, regulates. Associated with ALS, ALZHEIMER, ALZHEIMER'S. Connected to 3134 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	OXIDATIVE STRESS
Associated Diseases	ALS, ANXIETY, Aging, Alzheimer, Amyotrophic Lateral Sclerosis
Known Drugs/Compounds	RAPAMYCIN, RESVERATROL, L-DOPA, CURCUMIN, NICOTINAMIDE, DONEPEZIL
Interactions	UBIQUITIN, AMPK, INSULIN RESISTANCE, TNF-Α, HMGB1, BRAIN INFLAMMATION
KG Connections	5078 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    subgraph Pathology["Pathology"]
        OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"associated with"| ALS["ALS"]
        SOD1["SOD1"] -->|"associated with"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
        P62["P62"] -->|"associated with"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
        AUTOPHAGY["AUTOPHAGY"] -->|"associated with"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
        AKT["AKT"] -->|"associated with"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    end
    subgraph Therapeutic["Therapeutic"]
        OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"therapeutic target"| Als["Als"]
        OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"therapeutic target"| Fibrosis["Fibrosis"]
        OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"therapeutic target"| Diabetes["Diabetes"]
    end
    subgraph Signaling["Signaling"]
        OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"regulates"| Inflammation["Inflammation"]
        OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"regulates"| Autophagy["Autophagy"]
        OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"regulates"| Lipid_Metabolism["Lipid Metabolism"]
        OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"regulates"| Epigenetic["Epigenetic"]
        OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"regulates"| Oxidative_Stress["Oxidative Stress"]
        AUTOPHAGY_1["AUTOPHAGY"] -->|"activates"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
        APOPTOSIS["APOPTOSIS"] -->|"activates"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    end
    style OXIDATIVE_STRESS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
    style ALS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Als fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Inflammation fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Autophagy fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Lipid_Metabolism fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Epigenetic fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Oxidative_Stress fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Fibrosis fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Diabetes fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style SOD1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style P62 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style AUTOPHAGY fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style AUTOPHAGY_1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style APOPTOSIS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style AKT fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0

Outgoing (3857)

Target	Relation	Type	Str
ALS	associated_with	gene	1.00
Als	therapeutic_target	disease	1.00
Inflammation	regulates	disease	1.00
Autophagy	regulates	pathway	1.00
Lipid Metabolism	regulates	pathway	1.00
Epigenetic	regulates	pathway	1.00
Oxidative Stress	regulates	pathway	1.00
Fibrosis	therapeutic_target	disease	1.00
Diabetes	therapeutic_target	disease	1.00
Autophagy	therapeutic_target	pathway	1.00
Inflammasome	activates	pathway	1.00
Oxidative Stress	activates	pathway	1.00
NRF2	associated_with	gene	1.00
Als	associated_with	disease	1.00
Autophagy	associated_with	pathway	1.00
Oxidative Stress	associated_with	pathway	1.00
AUTOPHAGY	regulates	gene	1.00
UBIQUITIN	activates	gene	1.00
Als	regulates	disease	1.00
AMPK	activates	gene	1.00
Als	activates	disease	1.00
Inflammation	activates	disease	1.00
Autophagy	activates	pathway	1.00
Mtor	activates	pathway	1.00
Alzheimer	activates	disease	1.00
DIABETES MELLITUS	therapeutic_target	gene	1.00
TNF-Α	activates	gene	1.00
Stroke	activates	disease	1.00
Neuroinflammation	activates	disease	1.00
Nf-Κb	activates	pathway	1.00
Apoptosis	activates	pathway	1.00
Immune Response	activates	pathway	1.00
Mapk	activates	pathway	1.00
NRF2	activates	gene	1.00
Alzheimer	therapeutic_target	disease	1.00
Mitochondrial Function	activates	pathway	1.00
CANCER	activates	gene	1.00
AUTOPHAGY	activates	gene	1.00
Cancer	activates	disease	1.00
Tumor	activates	disease	1.00
Oxidative Stress	therapeutic_target	pathway	1.00
Tumor	associated_with	disease	1.00
Mitophagy	regulates	pathway	1.00
HO-1	activates	gene	1.00
Ferroptosis	activates	pathway	1.00
Oxidative Stress	contributes_to	pathway	1.00
Cancer	therapeutic_target	disease	1.00
Tumor	therapeutic_target	disease	1.00
Mitophagy	activates	pathway	1.00
Als	expressed_in	disease	1.00

Incoming (5992)

Source	Relation	Type	Str
P62	associated_with	gene	1.00
AUTOPHAGY	associated_with	gene	1.00
AUTOPHAGY	activates	gene	1.00
APOPTOSIS	activates	gene	1.00
AKT	associated_with	gene	1.00
KEAP1	activates	gene	1.00
NRF2	regulates	gene	1.00
NEURODEGENERATION	contributes_to	gene	1.00
ALZHEIMER'S DISEASE	associated_with	gene	1.00
PARKINSON'S DISEASE	associated_with	gene	1.00
MITOPHAGY	associated_with	gene	1.00
PARKINSON'S DISEASE	therapeutic_target	gene	1.00
PINK1	activates	gene	1.00
KEAP1	regulates	gene	1.00
APOPTOSIS	associated_with	gene	1.00
APOPTOSIS	inhibits	gene	1.00
APOPTOSIS	contributes_to	gene	1.00
NEURODEGENERATION	activates	gene	1.00
NEURODEGENERATION	associated_with	gene	1.00
APOPTOSIS	therapeutic_target	gene	1.00
TP53	associated_with	gene	1.00
TNF	associated_with	gene	1.00
FERROPTOSIS	associated_with	gene	1.00
NEUROINFLAMMATION	associated_with	gene	1.00
TNF	therapeutic_target	gene	1.00
NRF2	inhibits	gene	1.00
MIRNAS	therapeutic_target	gene	1.00
CASP3	associated_with	gene	1.00
NEURODEGENERATION	therapeutic_target	gene	1.00
TAU	associated_with	gene	1.00
ROS	inhibits	gene	1.00
ROS	activates	gene	1.00
ROS	regulates	gene	1.00
AMYLOID	associated_with	gene	1.00
ROS	associated_with	gene	1.00
NRF2	associated_with	gene	1.00
NEUROTOXICITY	activates	gene	1.00
NRF2	activates	gene	1.00
ALS	associated_with	gene	1.00
INSULIN RESISTANCE	activates	gene	1.00
NLRP3	activates	gene	1.00
ROS	therapeutic_target	gene	1.00
ROS	causes	gene	1.00
NATURAL COMPOUNDS	therapeutic_target	gene	1.00
KEAP1	inhibits	gene	1.00
TNF-Α	activates	gene	1.00
TAU	therapeutic_target	gene	1.00
ROS	treats	gene	1.00
ROS	implicated_in	gene	1.00
NEURODEGENERATION	implicated_in	gene	1.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

OXIDATIVE STRESS

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Parkinson's Disease

Sleep and Circadian Dysfunction in Alzheimer's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

CBS/PSP Supplements Guide

Atypical Parkinsonism

Device Therapies Comparison for CBS/PSP

Parthanatos in Neurodegeneration

calcium-dysregulation-comparison

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

Alpha-Synuclein Pathology

PD Combination Therapy Matrix

Alzheimer's Disease Mechanism Index

Corticobasal Degeneration (CBD)